We study macrophage signaling
pathways and therapeutic intervention in
chronic inflammatory diseases and
cancer.
Mirza S Baig, PhD
Professor, Department of Biosciences & Biomedical Engineering
PhD, CSIR-Central Drug Research Institute, India (2008)
Postdoc, University of Illinois at Chicago and Mayo Clinic Rochester, USA (2014)
Macrophage: AMIGO O ENEMIGO?
Macrophages are a type of leukocyte that are widely distributed throughout the tissues and display a huge functional heterogeneity. They perform a wide range of functions such as detecting pathogens, breaking down cellular waste, and producing important cytokines and regulatory factors throughout the body. In recent years, there has been significant interest in the role of macrophages in human diseases associated with chronic inflammation, including atherosclerosis, obesity, diabetes, skin diseases, neurodegenerative diseases, and even cancer.
However, our understanding of the signaling pathways and molecular mechanisms that define the diverse role of macrophages in different pathophysiological conditions is still limited. Our goal is to create a comprehensive understanding of macrophage signaling pathways and mechanisms, with the aim of modifying macrophage behavior. By gaining a detailed understanding of these processes at the molecular level, it would be possible to develop precise and targeted therapies for chronic inflammatory diseases and cancer.